Celanese Eva Performance Polymers Corporation

Equistar Chemicals, LP

Jeffrey C Haley

Harilaos Mavridis

Sameer D Mehta

Philip J Garrison

Jeffrey S Borke

Christian Schneider

Dirk Hair

Vijay Gyanani

Harsh Patel

An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a plurality of water-soluble particles distributed within a membrane polymer matrix containing an ethylene vinyl acetate copolymer, wherein the water-soluble particles have a D50 particle size of about 150 micrometers or less and contain a non-polymeric, hydroxy-functional compound.

Implantable device for sustained release of a macromolecular drug compound

Growing community of inventors

Norwood, OH, United States of America

Jeffrey C Haley