Ortho Pharmaceutical Corporation

Emisphere Technologies, Inc.

Jeffrey Bruce Press

Andrea Leone-Bay

Koc-Kan Ho

David Gschneidner

Eric Yanjun Wang

Nai Fang Wang

Pingwah Tang

Lynn Errigo

Robert E Boyd

Chris R Rasmussen

Robert Falotico

James J McNally

Ramesh M Kanojia

Victor T Bandurco

Pauline J Sanfilippo

Zoltan G Hajos

Robert A Mallory

Harvey M Werblood

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Compounds and compositions for delivering active agents

Described herein are 4-�(thien-3-yl)methyl!-imidazoles of the formula: ##STR1## wherein R is hydrogen or methyl, and

4-�(thien-3-yl)methyl!-imidazole analgesics

The 4-[(thien-2-yl)methyl]-imidazoles of the formulae: ##STR1## wherein R is hydrogen or methyl,

4-[(thien-2-yl)methyl]-imidazole analgesics

Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents

Substituted thienopyrans as antihypertensive agents

Substituted benzhydryl 2-hydroxypropyl piperazine derivatives and methods of synthesis of the derivatives are described. The substituted benzhydryl 2-hydroxypropyl piperazine derivatives are useful as cardiotonic agents.

Substituted benzhydryl 2-hydroxypropyl piperazine derivatives

Novel 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.

2- or 3-aryl substituted imidazo[1,2-a]pyridines

A process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their metal salts is described. The diones are active cardiotonic agents.

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Brewster, NY, United States of America

Jeffrey Bruce Press