Hill's Pet Nutrition, Inc.

The Translational Genomics Research Institute

Jeffrey Brockman

Dennis Edward Jewell

Steven Curtis Zicker

Dale S Scherl

Albert Avila

Christina Golder

Stephen Davidson

Nolan Zebulon Frantz

Samer Al-Murrani

Matthew Huentelman

Matthew Jackson

Kiran Panickar

Eden Ephraim

Laura Morgan

Matthew J Huentelman

Dale Scherl

Methods of identifying canine subjects having an increased likelihood of developing elevated levels of 4-ethylphenyl sulfate, canine stress, canine anxiety and/or an inhibition of growth of beneficial microbes and promotion of growth of harmful microbes are disclosed. Methods comprise analyzing a biological sample obtained from the canine subject for the presence of two copies of a minor allele of the single nucleotide polymorphism BICF2P1175095 in a canine subject. Methods of treating the identified canine subjects by administering an effective amount of tomato pomace are also disclosed. Methods of treating canine subjects for elevated 4-EPS levels, canine anxiety or canine stress are disclosed. Canine food compositions that comprises tomato pomace are disclosed.

Compositions and methods of treating and reducing risk of conditions associated with elevated 4-ethylphenyl sulfate in canines and identifying canines at risk of such conditions

Methods of analyzing a biological sample obtained from the canine subject for the presence of one or two copies one or two copies of minor allele T of SNP Affx-206229307; or one or two copies of minor allele A of SNP Affx-206560187; or one or two copies of minor allele T of SNP Affx-206229307 and one or two copies of minor allele A of SNP Affx-206560187 are disclosed. The methods are used in methods to identify a canine subject that has an increased likelihood or risk of hypothyroidism and in methods of treating a canine subject to reduce risk of hypothyroidism or to treat a canine subject that has hypothyroidism. The treatments comprise administering to the canine subject a low arginine diet and/or comprising an effective amount of a composition comprising a protein source, a carbohydrate source, a vegetable source, and a fruit source. Canine food compositions are disclosed.

Reagents, kits and methods for assessing and reducing risk of developing canine hypothyroidism and other autoimmune conditions

Described herein are kits for assessing the calcium oxalate titration test of an animal as well as methods for predicting the risk of calcium oxalate stone formation. Further described herein are methods and compositions for&#x2014;inter alia&#x2014;lowering the specific gravity of urine and lowering the calcium oxalate titration test in felines. In particular, diets and methods utilizing certain amounts and ratios of arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are disclosed herein.

Calcium oxalate titration test kits and pet food compositions

Described herein are methods and compositions for&#x2014;inter alia&#x2014;lowering the specific gravity of urine and lowering the calcium oxalate risk index of in felines. In particular, diets and methods utilizing certain amounts and ratios of arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Pet food compositions

Methods of analyzing a biological sample obtained from the feline subject for the presence of two copies of major allele G of SNP A1_212891692 and/or to the concentration of betaine and/or 2-oxoarginine in the sample are disclosed. The methods are used in methods to identify a feline subject that would benefit from a treatment that reduces risk of calcium oxalate stone formation and in methods of treating a feline subject to reduce risk of calcium oxalate stone formation The treatment on comprises administering to the feline subject a composition that comprises an effective amount of one or more of ingredients selected from the group consisting of betaine, green tea, fenugreek and tulsi. Feline food composition that comprise effective amounts of betaine, green tea, fenugreek and tulsi are disclosed.

Methods for identifying a companion animal susceptible to treatment that reduces the risk of stone formation and compositions for reducing such risk

The present invention encompasses compositions and methods for the prevention and treatment of age related conditions in animals, particularly in companion animals, in need thereof. The methods for treating or preventing an age-related condition in an animal in need thereof, comprise administering to the animal an effective amount of a composition comprising at least one of a protein source, a carbohydrate source, a vegetable source, a fruit source, or a combination of two or more thereof. In this method, the protein source is selected from the group consisting of chicken, egg protein, corn gluten meal, and combinations thereof; the carbohydrate source is selected from the group consisting of millet, brewers rice, oat groats, and combinations thereof, the vegetable source is selected from the group consisting of carrots, spinach, tomato pomace, and combinations thereof, wherein the fruit source is citrus pulp.

Anti-aging foods for companion animals

The disclosure includes methods of identifying a dog at risk of developing a an autoimmune disease or condition, for example a hypothyroid disease or condition, comprising testing whether the dog exhibits one or more selected single nucleotide polymorphisms (SNPs), together with diagnostic kits for carrying out such methods, methods of treatment or prophylaxis of such autoimmune disease or condition, e.g., comprising administering an effective amount of tea extract to a dog in need thereof, and a canine diet or supplement comprising tea extract, useful for treatment of prophylaxis of such autoimmune disease or condition, or for maintenance of thyroid health in a dog.

Canine autoimmune conditions and diagnosis and treatment thereof

Methods and compositions for hydrating cats. Cats fed diets containing certain amounts and ratios of arachidonic acid and eicosapentaenoic acid will be sufficiently hydrated and at reduced risk for development of urinary stones, feline idiopathic cystitis, or FLUTD.

Improving the level of hydration in a cat

The invention encompasses methods for inhibiting histamine release pathways in a companion animal, for example, felines and in treating or preventing idiopathic cystitis or interstitial cystitis. The compositions and methods of the invention include an amount of lipoic acid that is effective in inhibiting histamine release pathways in a companion animal, for example, felines and in treating or preventing idiopathic cystitis or interstitial cystitis.

Antioxidant-containing food composition for use in inhibiting histamine pathways in companion animals

An isolated DNA molecule comprising a fragment of the gene encoding the feline NIS is disclosed as well as methods of use thereof. Also provided are methods for rational diet design of food composition suitable for administration to feline companion animals afflicted with hyperthyroidism, comprising (a) accessing at least one database that comprises a first data set relating functional gene profile of a biofluid or tissue sample from an animal to physiological condition of the animal, where the functional gene profile is that of the feline NIS gene; (b) accessing at least one database that comprises a second data set relating effects of bioactive dietary components on the functional gene profile; (c) using an algorithm drawing on these data sets, processing input data defining physiological condition to derive a nutritional formula promoting wellness of a feline companion animal afflicted with hyperthyroidism; and (d) preparing a food composition based on the nutritional formula.

Compositions and methods for diagnosing and treating hyperthyroidism in companion animals

The invention encompasses compositions for enhancing the ability of a companion animal to resist and/or overcome viral infections. The compositions of the invention include an amount of lipoic acid that is effective in enhancing the antiviral immunity of a companion animal.

Growing community of inventors

Lawrence, KS, United States of America

Jeffrey Brockman