Smart Holograms Limited

Cambridge Enterprise Limited

Cambridge University Technical Services Limited

Jeffrey Blyth

Christopher Robin Lowe

Satyamoorthy Kabilan

Anthony Peter James

Colin Alexander Bennett Davidson

Roger Bradley Millington

Alexander James Marshall

Barry Burles

Blanca Madrigal Gonzalez

Mei-Ching Lee

Felicity Kate Sartain

Xiaoping Yang

Abid Hussain

Kathryn Elizabeth Sorrell Medlock

Adrian Martin Horgan

Andrew Geoffrey Mayes

Gita Khalili Moghaddam

A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising the steps of: a) introducing a colloidal dispersion of a recording material into the support medium; and b) ablating the colloidal particles of the recording material using a pulsed laser to form the holographic element in the support medium. The method of production can be used to introduce a reflection holographic grating into a hydrophobic support medium, in particular, polydimethylsiloxane (PDMS), which possesses an extraordinary ability to swell in the presence of both liquid and/or gaseous low molecular weight hydrocarbons and organic solvents and thus has many applications as a holographic sensor.

Method of production of a holographic sensor

A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.

Boronate complex and its use in a glucose sensor

A sensor for the detection of an analyte, comprising a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the hologram changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the medium is obtainable by formation in situ in the presence of a pore-forming agent, wherein the agent is not present in the sensor or does not react with the analyte and the sensor.

Method for forming a volume holographic sensor in a porous medium

An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.

Ophthalmic device comprising a holographic sensor

A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose. 

Holographic sensor

A sensing method, which comprises subjecting a holographic sensor to an external physical interaction to which the sensor is sensitive, and observing a change in the holographic image.

Sensing method including interrogation of a holographic sensor

An array of discrete sensors disposed on a substrate, each sensor comprising a holographic support medium and a hologram disposed throughout the volume of the medium, whereby interaction with an analyte results in a variation of a property of the medium.

Holographic sensors and their production

A method for the detection of an analyte in a fluid, comprising contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the variation arises as a result of interaction between the medium and the analyte, and wherein the reaction and the variation are reversible; and detecting any change of the optical characteristic.

Method of detecting an analyte in a fluid

A method for the production of a holographic sensor wherein the holographic recording material forming the sensitive element is a polymer matrix, which comprises diffusing into the matrix one or more soluble salts that undergo reaction in situ to form an insoluble sensitive precipitate; and recording a holographic image. This method allows the production of a holographic sensor wherein the holographic recording material forming the sensitive element is an insoluble polymer film.

Growing community of inventors

Cambridge, United Kingdom

Jeffrey Blyth