The United States of America, As Represented by the Secretary, Department of Health and Human Services

Jeffrey B Kopp

George E Nelson

Michael W Smith

Terence M Phillips

Cheryl Winkler

Randall Johnson

Ulrich Schubert

John Yewdell

John Yewell

Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed.

Single nucleotide polymorphisms associated with renal disease

The present invention provides monoclonal antibodies to HIV-1 Vpr and hybridoma cell lines that produce the monoclonal antibodies to HIV-1 Vpr. Methods for use of such antibodies in the detection of HIV-1 infection are also provided.

Monoclonal antibodies to HIV-1 and methods of using same

Growing community of inventors

Bethesda, MD, United States of America

Jeffrey B Kopp