Georgetown University

Jeffrey A Toretsky

Milton L Brown

Yali Kong

Aykut Uren

Aykut Üren

Perrer N Tosso

Haydar Celik

Aykut Ueren

Milton Lang Brown

Provided herein are methods of treating a bone or connective tissue cancer in a subject. The methods comprise administering to the subject an effective amount of a CD99 inhibitor, wherein the CD99 inhibitor is a compound having the formula  wherein R, each of which may be the same or different, is hydrogen, or a protecting group; wherein Z is selected from the group consisting of F, Cl and Br; wherein X is H or F; and pharmaceutically acceptable salts thereof.

CD99 inhibitors and their uses

Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

Targeting of EWS-FLI1 as anti-tumor therapy

Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

Methods and compositions for treating Ewings sarcoma family of tumors

Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

Growing community of inventors

Silver Spring, MD, United States of America

Jeffrey A Toretsky