The Medical College of Wisconsin, Inc.

University of Virginia Patent Foundation

Jeffrey A Medin

Lawrence G Lum

Daniel H Fowler

Robyn A A Oldham

Archana Thakur

Everett R Tate

Robert Blake Hill

Mary L Faber

Murtaza S Nagree

Robyn A Oldham

Kaothara Oluwakemi Adeyanju

Tania Felizardo

The present invention provides novel bispecific antibodies that bind to human CD30 and uses thereof. Methods of treating cancer using the bispecific antibodies described herein are also provided.

Anti-CD30 and anti-CD3 bispecific antibodies and methods of immunotherapy for CD30+ malignancies

The present invention provides novel antibodies and antigen binding fragments thereof that bind to human CD30. Also presented are single chain variable antibodies, chimeric antigen receptors and uses thereof. Methods of treating cancer are also disclosed.

Anti-CD30 antibodies

The present disclosure provides methods of treating lysosomal storage disorders, e.g., Fabry disease, Gaucher disease, Farber disease, and Pompe disease. The method comprises producing vector-transduced T-Rapa cells that express a transgene of interest and administering the cells to a patient in need thereof. The T-Rapa cells may be transduced with a dual promoter lentivirus vector.

Use of lentivector-transduced T-Rapa cells for amelioration of lysosomal storage disorders

The present disclosure provides chimeric antigen receptor (CAR)-T-Rapa cells and methods of making and using them. Specifically, methods of producing T-Rapa cells that can express chimeric antigen receptors is provided.

T-Rapa cells as novel effector cell type for chimeric antigen receptor therapy

The present disclosure provides soluble truncated mutant programmed death-ligand 1 (PD-L1) peptides. Polynucleotides and vectors encoding the soluble truncated mutant PD-L1 peptides are also provided. Further, methods of using the soluble truncated mutant peptides to promote differentiation of CD4+ effector T (Th1) cells into Foxp3+ regulatory T (Treg) cells are provided.

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Shorewood, WI, United States of America

Jeffrey A Medin