Signal Pharmaceuticals, Inc.

Novartis Ag

Jeffrey A McKie

Shripad S Bhagwat

Bernd M Stein

Leah Marie Gayo-Fung

Qi Chao

Kenneth D Rice

Sophie Perrin-Ninkovic

Jonathan Wright

Anthony R Gangloff

Glenn Friedman

Sak Khammungkhune

Adam Kois

Graziella I Shevlin

Johanne Renaud

Martin Missbach

David Wesley Anderson

Ravi Kumar Jalluri

Mary Doubleday

May S Sutherland

This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyranone Compound. The Benzopyranone Compounds have the formula: or a pharmaceutically acceptable salt thereof, wherein Ris halogen, trifluoromethyl or Calkyl.

Methods for treating or preventing metastatic cancer using benzopyranone compounds

Methods for treating or preventing cancer using Benzopyranone Compounds

Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-&#x3b2; over ER-&#x3b1;. Methods are disclosed for modulating ER-&#x3b2; in cell and/or tissues expressing the same, including cells and/or tissue that preferentially ER-&#x3b2;. Methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natureal hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.

Compounds and methods for modulation of estrogen receptors

Benzopyranone Compounds having the following structure: 

Benzopyranone compounds, compositions thereof, and methods of treatment therewith

Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer

Benzopyrazone compounds, compositions thereof, and methods of treatment therewith

Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-&bgr; over ER-&agr;. Methods are disclosed for modulating ER-&bgr; in cell and/or tissues expressing the same, including cells and/or tissue that preferentially ER-&bgr;. Methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natureal hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.

Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-&bgr; over ER-&agr;. Methods are disclosed for modulating ER-&bgr; in cell and/or tissues expressing the same, including cells and/or tissue that preferentially express ER-&bgr;. More generally, methods for treating estrogen-related conditions are also disclosed, including conditions such as is breast cancer, testicular cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, urinary incontinence, hairloss, cataracts, natural hormonal imbalances, and adverse reproductive effects associated with exposure to environmental chemicals.

Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same:

Growing community of inventors

San Diego, CA, United States of America

Jeffrey A McKie