Baxter International Inc.

Other

Jeffrey A Martinson

John R Chapman

William R Bratten

Li Ming Wang

Daniel F Bischof

Dennis E Van Epps

Richard C Giesler

Dale R Ellis

William C Lake

Frederick Aono

James Bender

Stephen L Smith

Kristen L Unverzagt

Maureen Loudovaris

Orrin D Mitsven, Jr

A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating lymphocyte cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.

Continuous process for the separation of biologic components from

A method and apparatus for creating a leukocyte rich sample from a mixed population of blood cells. The method comprises the steps of: separating an amount of blood into layers that include a buffy coat layer having a mixed population of blood cells including plasma and red blood cells; providing a chamber having an opening for receiving a fluid; causing the buffy coat layer to enter the chamber; centrifuging the chamber to separate the buffy coat layer into at least a plasma containing layer, a leukocyte containing layer, and a red blood cell containing layer; and separating the leukocyte containing layer from the other layers in the chamber.

Method and device for testing blood units for viral contamination

Method for creating a leukocyte rich sample from a mixed population of

Continuous centrifugation process for the separation of biological

The present invention provides an apparatus for holding and carrying a plurality of flexible medical containers. The carrier has a rack having a plurality of plates positioned in parallel spaced relation, the plates defining a chamber between each pair of adjacent plates. A plurality of spacer assemblies each extend through the rack to connect the plates and to maintain their spaced relationship. The spacer assemblies are spaced along marginal edges of the rack to define two opposed end walls, a bottom, and an opening to the rack to allow access to each of the chambers. A flange extends from one of the plates and has a hole that allows the carrier to be suspended. The invention further provides for a system for transferring fluids and a method for mixing solutions using the carrier.

Apparatus for carrying flexible containers and method of transferring

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Mundelein, IL, United States of America

Jeffrey A Martinson