UniversitÈ Laval

The Hospital for Sick Children

Jeffrey A M Coull

Yves De Koninck

Paul De Koninck

Michael W Salter

Simon Beggs

Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of neuroglia-derived BDNF expression or activity. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing compounds for the treatment of pain and the reduction of nociception are also described.

Modulation of neuroglia-derived BDNF in the treatment and prevention of pain

Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing a compound for the treatment of pain, the reduction of nociception and the diagnosis and prognostication of pain are also described.

Method for identifying compounds for treatment of pain

The present invention provides methods of preventing and treating pain, by modulating, e.g. inhibiting, the activity, function and/or expression of a PLCin a subject. The invention further relates to methods of identifying agents capable of modulating the activity and/or expression of a PLC, or capable of modulating binding of a ligand or binding partner to a PLC, and their use thereof for the prevention and/or treatment of pain. In a further aspect, the invention provides methods for the diagnosis and prognostication of pain by determining whether there is modulation of activity and/or expression of a PLCrelative to a corresponding control.

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Toronto, Canada

Jeffrey A M Coull