Millennium Pharmaceuticals Limited

Jeffrey A Ecsedy

Karthik Venkatakrishnan

Arijit Chakravarty

Robert W Kleinfield

Wen Chyi Shyu

Kha N Le

Mengkun Zhang

Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient an Aurora kinase inhibitor such as 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid or a pharmaceutically acceptable salt in combination with a platin. Also disclosed are medicaments for use in the treatment of cancer.

Administration of aurora kinase inhibitor and chemotherapeutic agents

Disclosed are methods for the treatment of various cell proliferative disorders. Disclosed in particular are methods for treatment of various cell proliferative disorders by administering a selective inhibitor of Aurora A kinase in combination with taxane-based chemotherapy, such as paclitaxel or docetaxel.

Methods of treating cancer using aurora kinase inhibitors

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Newton, MA, United States of America

Jeffrey A Ecsedy