Vanderbilt University

Jeffrey A Clanton

Robert M Kessler

Tomas De Paulis

Howard E Smith

Aaron Janowsky

Aaron Janowski

Val M Runge

Thomas De Paulis

Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D2 receptor in the mammalian brain. These compounds have a specific combination of lipophilicity and dopamine D2 receptor affinity required to attain a required image contrast. The iodinated benzamides identified by the above discovery can be made by reacting a trialkyltin substituted benzamide with an acid in the presence of radioactive iodine which, in turn, is generated by in situ oxidation of an appropriate iodide nuclide salt.

Radioiodinated benzamines and method of their use as radioimaging

Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.

Radioiodinated benzamines method of their use as radioimaging agents

Contrast media compositions for nuclear magnetic resonance (NMR) imaging of the gastrointestinal system are provided for oral or rectal administration. The compositions comprise aqueous suspensions of particles of an NMR contrast agent, the particles being very finely-divided and providing in their outer surfaces a substantially water-insoluble paramagnetic compound. Suspending and/or wetting agents may be included to maintain the contrast agent particles in a dispersed, suspended condition for the oral or rectal administration. Buffering agents may also be included to maintain the pH of the suspension in a pH range protecting the insolubility of the paramagnetic compound.

Particulate NMR contrast agents for gastrointestinal application

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Nashville, TN, United States of America

Jeffrey A Clanton