Johns Hopkins University

Jeffrey A Brinker

Gordon Tomaselli

Chao-Wei Hwang

Gary Gerstenblith

Robert G Weiss

Peter V Johnston

Steven P Schulman

Zhiyong Xia

Virginia E Bogdan

George L Coles

Jason J Benkoski

Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.

Cell impregnated sleeve for paracrine and other factor production

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

Methods for promoting healing of tissue

Growing community of inventors

Baltimore, MD, United States of America

Jeffrey A Brinker