Curis, Inc.

Johns Hopkins University

Jeffery Porter

Stephen Colin Price

Maria Frank-Kamenetsky

Edward Andrew Boyd

Lee L Rubin

Oivin M Guicherit

Anthony David Baxter

John Harry Alexander Stibbard

Philip Arden Beachy

Michael K Cooper

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS.and. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Small organic molecule regulators of cell proliferation

The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.

Inhibitors of hedgehog signaling pathways, compositions and uses related thereto

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Lexington, MA, United States of America

Jeffery Porter