Baxano, Inc.

Pulson, Inc.

Amendia, Inc.

Baxano Surgical, Inc.

Spinal Elements, Inc.

Baxano Signal, Inc.

Jeffery Lee Bleich

Michael P Wallace

Paul David Mannheimer

Gregory Paul Schmitz

Vahid Saadat

Edwin J Hlavka

Roy Leguidleguid

Jefferey C Bleam

Ronald Leguidleguid

Nestor C Cantorna

Robert J Garabedian

Steven A Spisak

Gregory B Arcenio

Michael Sheinberg

James Shapiro

Winnie Chung

Darin Howard Buxbaum

John E Ashley

James Rolfe Yurchenco

Kenneth J Michlitsch

Amie R Borgstrom

Eric C Miller

David J Miller

Ron Leguidleguid

David John Miller

James Yurchenco

Winnie Tang

Christopher D Summa

Jeffrey Lawrence Michels

Marc David Anker

Benjamin Kao-Shing Sun

David R Miller

Described herein are systems and methods of guiding a user to achieve musculoskeletal counterpulsation. A method may include receiving a cardiovascular cycle signal from a first sensor; determining a heart rate of the user based on the cardiovascular cycle signal; receiving a rhythmic musculoskeletal activity timing signal from a second sensor; determining an actual musculoskeletal activity cycle (MSKC) to cardiovascular cycle (CC) timing relationship; comparing the actual MSKC to CC timing relationship to a target MSKC to CC timing relationship; providing a recurrent prompt to the user as a timing indication for performance of a rhythmic musculoskeletal activity to guide the user to achieve a musculoskeletal activity cycle rate (MSKR) that approaches the target MSKC to CC timing relationship; and altering a feature of the recurrent prompt based on a determined alignment between the actual MSKC to CC timing relationship and the target MSKC to CC timing relationship.

Systems and methods for coordinating musculoskeletal and cardiovascular or cerebrovascular hemodynamics

Described herein are devices, systems and methods for treating target tissue in a patient's spine. In general, the methods include the steps of advancing a wire into the patient from a first location, through a neural foramen, and out of the patient from a second location; connecting a tissue modification device to the wire; positioning the tissue modification device through the neural foramen using the wire; modifying target tissue in the spine by moving the tissue modification device against the target tissue; and delivering an agent to modified target tissue, wherein the agent is configured to inhibit blood flow from the modified target tissue. In some embodiments, the step of modifying target tissue comprises removing target tissue located ventral to the superior articular process while avoiding non-target tissue located lateral to the superior articular process.

Devices and methods for treating tissue

Described herein are systems and methods for favorably coordinating a timing relationship between a musculoskeletal activity cycle and a cardiac cycle of a user. A method may include repetitively detecting a signal that correlates to a blood volume in the user; determining an actual value of the signal that varies with the timing relationship; computing a trend of the actual value of the signal; and adjusting the movement guidance based on the trend of the actual value. A system may include a prompt device configured to provide recurrently a movement guidance to the user for guiding performance of the rhythmic musculoskeletal activity; a sensor configured to provide a signal that correlates to a blood volume in the user; and a processor configured to determine an actual value of the signal that varies with the timing relationship and to adjust the movement guidance based on the trend of the actual value.

Systems and methods for coordinating musculoskeletal and cardiovascular hemodynamics

The present invention is generally directed to methods, systems, and computer program products for coordinating musculoskeletal and cardiovascular hemodynamics. In some embodiments, a heart pacing signal causes heart contractions to occur with an essentially constant time relationship with respect to rhythmic musculoskeletal activity. In other embodiments, prompts (e.g., audio, graphical, etc.) are provided to a user to assist them in timing of their rhythmic musculoskeletal activity relative to timing of their cardiovascular cycle. In further embodiments, accurately indicating a heart condition during a cardiac stress test is increased.

Coordinating musculoskeletal and cardiovascular hemodynamics

Described herein are methods for determining a target musculoskeletal activity cycle (MSKC) to cardiac cycle (CC) timing relationship. The method may include detecting a signal responsive to a cyclically-varying arterial blood flow at a location on a head of a user; providing a recurrent prompt at a frequency of the heart pump cycle using the signal, such that the signal correlates with a magnitude of blood flow adjacent to the location, and the recurrent prompt is provided to guide the user to time performance of a component of a rhythmic musculoskeletal activity with the recurrent prompt; and guiding the user to adjust a timing of the component of the rhythmic musculoskeletal activity to substantially maximize a magnitude of the signal. In some embodiments, the method further includes generating the recurrent prompt by amplifying the sound generated by the blood flow in or in proximity to an ear of the user.

The present invention is generally directed to methods, systems, and computer program products for coordinating musculoskeletal and cardiovascular hemodynamics, and more directly to stationary and non-stationary exercise equipment that include adjustable behaviors and are used with repetitive activities. The equipment is adjusted automatically in real-time to alter the work output, cadence, and/or timing of the user's physical activity in response to their monitored cardiovascular and musculoskeletal signals to achieve and maintain a targeted coordination of their heart and musculoskeletal pump cycle timing.

Described herein are methods for determining a target musculoskeletal activity cycle (MSKC) to cardiac cycle (CC) timing relationship. The method may include detecting a first characteristic of a signal responsive to a CC timing of a user that repeats at a frequency that corresponds to a heart rate of the user; detecting a second characteristic of a signal responsive to a rhythmic musculoskeletal cycle activity (MSKC) timing of the user that repeats at a frequency that corresponds to the MSKC rate of the user; determining a value representative of an actual timing relationship between the first characteristic and the second characteristic; detecting a third characteristic of a signal corresponding to a physiological metric that varies with the actual timing relationship between the first and second characteristics; and determining a target value representative of a preferred timing relationship between the first and second characteristics.

Described herein are elongate devices for modifying tissue having a plurality of flexibly connected rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on (or formed from) rungs that are flexibly connected. The rungs are typically rigid, somewhat flat and wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used. The blades (on the rungs) may be arranged in a staggered arrangement. A tissue-collection or tissue capture element may be used to collect the cut or modified tissue.

Tissue modification devices

Growing community of inventors

Palo Alto, CA, United States of America

Jeffery Lee Bleich