Smithkline Beecham Corporation

Jeffery L Wood

Joseph Marian Fortunak

John Kitteringham

Robert John Mills

Marvin Sungwhan Yu

Lendon Norwood Pridgen

Nicholas Sisti

Qiaogong Su

Michael Anthony McGuire

Mark Mellinger

Michael Anthnoy McGuire

Process for preparing indane carboxylate and cyclopentano &lsqb;6&rsqb; pyridine derivatives

Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic

The present invention provides a process for the asymmetric synthesis of camptothecin analogs as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analog, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analog. ##STR1##

Process for asymmetric total synthesis of camptothecin analogues

The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue. ##STR1##

A method for making 8-methyl-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-ones from 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12 H)-diones, said method being graphically illustrated as follows: ##STR1##

Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]quinolinones

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Blue Bell, PA, United States of America

Jeffery L Wood