Other

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Jeffery J Feigenbaum

Raphael Mechoulam

Naphtali Lander

Morris Srebnik

The invention relates to novel (3S,4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinol homologes and derivatives, essentially free of the (3R,4R) form and to pharmaceutical compositions which have a potent analgetic, antiemetic and antiglaucoma effect, which compositions contain an effective dosage of a compound of this type. The novel pharmaceutical compositions are practically devoid of the undesired side effects of the (3R,4R) type compounds, such as cannabimimetic psychotropic effects. The pharmaceutical compositions are of special utility in cases of acute and of chronic pain. The invention also relates to a process for the production of the above defined novel compounds.

(3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols

There are provided 3-(6-alkoxy-4-alkyl-2-hydroxyphenyl) cyclohexanol derivatives and pharmaceutical compositions containing these as active ingredient. These are useful as potent analgesics and also as antiemetics. The compounds have the advantage of being devoid of psychotropic activity.

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Jerusalem, Israel

Jeffery J Feigenbaum