Merck Sharp + Dohme Corp.

Schering Corporation

Jeffery Grein

Daniel M Gorman

Terrill K McClanahan

Christi L Parham

Jeanine D Mattson

Theodore R Sana

Erin E Murphy

Naoko Arai

Hirokazu Kurata

Chetan Savkoor

Kathleen M Smith

Juha Punnonen

Alissa A Chackerian

Drake LaFace

David Bauche

Smita Mauze

Lakshmanan Annamalai

Anandi Sawant

Edward Bowman

Anti-cancer combination therapies comprising a CTLA-4 blocking agent and a PD-1 blocking agent are disclosed. In particular, combination therapies are disclosed wherein the CTLA-4 blocking agent is an effector-silent anti-CTLA-4 antibody or effector-silent anti-CTLA-4 antibody fragment and the PD-1 blocking agent is an anti-PD-1 or anti-PD-L1 antibody, or antibody fragment thereof.

Anti-cancer combination therapies comprising CTLA-4 and PD-1 blocking agents

Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

Nucleic acids encoding TNF&#x3b3;

Nucleic acid encoding TNFx protein

Growing community of inventors

Cupertino, CA, United States of America

Jeffery Grein