University of Pennsylvania

Jeffery G Saven

Renyu Liu

Jin Xi

Felipe Matsunaga

Jose Manuel Perez-Aguilar

Alan T Johnson

Mitchell Lerner

Ganghee Han

The present invention provides methods for fabricating field-effect devices and sensor arrays. The field of the invention also pertains to methods of using the sensors individually, in combination, and in array fashion to detect molecules. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.

Opioid detection based on high quality graphene transistor arrays and a synthetic mu receptor

Described herein are recombinant integral membrane proteins having multiple transmembrane domains that have been engineered to be less hydrophobic, through alteration of the amino acid sequence of the native protein, but retain the ability to bind their natural ligand. The decreased hydrophobicity of the described proteins makes them more water soluble than the native protein, which allows the described proteins to be expressed in bacteria in large quantities and isolated in the absence of membranes, all while retaining the ability to interact with known ligands.

Water soluble G-protein coupled receptor

Growing community of inventors

Philadelphia, PA, United States of America

Jeffery G Saven