Merck Sharp + Dohme Corp.

Jeffery G Aaronson

Matthew G Stanton

Rob Burke

Steven L Colletti

Thomas Joseph Tucker

Weimin Wang

Rubina G Parmar

David M Tellers

Kathleen B Calati

Boyoung Kim

Disclosed herein is a peptide containing conjugate comprising (P)-(L)-(G), wherein P is a peptide and each occurance of P is independently selected from Table 2; L is an optional linker and each occurance of L, if present, is independently selected from Table 3; G is a targeting ligand and each occurance of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)-(G), wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.

Peptide containing conjugates for dual molecular delivery of oligonucleotides

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Philadelphia, PA, United States of America

Jeffery G Aaronson