University of California

University of Pittsburgh

Avidbiotics Corporation

Jeffery F Miller

Robert L Modlin

Huiying Li

Shuta Tomida

Sorel T Fitz-Gibbon

David W Martin, Jr

Graham F Hatfull

Robert Damoiseaux

Asher Hodes

Min Xu

Mari Gingery

Philip Bulterys

Christopher Todd French

Laura J Marinelli

Sergei Doulatov

David W Martin

(Bp) and(Bm) are Tier-1 select pathogens that cause highly lethal human infections with limited therapeutic options. Intercellular spread is a hallmark ofpathogenesis and its prominent ties to virulence make it an attractive therapeutic target. We developed a high-throughput cell-based phenotypic assay and screened ˜220,000 small molecules for their ability to disrupt intercellular spread by, a BSL-2 surrogate for these pathogens. 268 hits were identified, and cross-species validation found 32 hits that also disrupt intercellular spread by Bp and/or Bm. In a fulminant murine model of respiratory melioidosis, treatment with a number of these agents was significantly more effective than ceftazidime, the current drug of choice, for improving patient survival and decreasing bacterial counts in major organs.

Discovery of novel anti-infectives for gram negative pathogens

In certain aspects, the disclosure relates to compositions and methods relating to mutant bacteriophage that target. In certain aspects, compositions and methods described herein are useful for the treatment of acne.

Compositions and methods for treating acne

Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne include administering an effective amount of a drug specifically targeting RT4, RT5, RT7, RT8, RT9, or RT10, such as small molecules, antisense molecules, siRNAs, biologics, antibodies, phages, vaccines, or combination thereof.

Fast diagnosis and personalized treatments for acne

This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention thus provides nucleic acid molecules to be diversified, as well as those which act as the template region (TR) and in concert with the TR for directional, site-specific diversification. Further provided are methods of preparing and using these nucleic acid sequences.

Site specific system for generating diversity protein sequences

Growing community of inventors

Santa Monica, CA, United States of America

Jeffery F Miller