Biohaven Therapeutics Ltd.

Biohaven Pharmaceutical Holding Company Limited

Rutgers, The State University of New Jersey

Jeffery Claude Pelletier

Allen B Reitz

Jay Edward Wrobel

Garry Robert Smith

Haiyan Bian

Mark E McDonnell

Benjamin E Blass

Suzie Chen

Matthew D Vera

Venkata N Velvadapu

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Riluzole prodrugs and their use

Disclosed are acyl benzo[d]thiazol-2-amines having a structure according to formula (I): including enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof. The compounds may be useful for the treatment of various diseases including, for example, neurological disorders such as amyotrophic lateral sclerosis, bipolar disorder, treatment resistant and major depression, general anxiety disorder, and cancers such as melanoma, breast cancer, brain cancer, and prostate cancer.

Acyl benzo[d]thiazol-2-amine and their methods of use

Prodrugs of riluzole and their method of use

Pharmaceutical compositions of the invention include substituted Lanicemine prodrugs useful for the treatment of conditions associated with dysregulation of NMDA receptor activity such as depression and depressive disorders through the release of Lanicemine, Prodrugs of Lanicemine have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release Lanicemine in the plasma via either an enzymatic or general biophysical release process.

Prodrugs of lanicemine and their method of use

Growing community of inventors

Lafayette Hill, PA, United States of America

Jeffery Claude Pelletier