University of California

Demetrix, Inc.

Jeff Wong

Jay D Keasling

Charles Denby

Leo D'Espaux

Xiaozhou Luo

Michael Reiter

Anna Lechner

Darren Platt

Jeff Ubersax

Andrew Horwitz

The present disclosure provides engineered variants of a cannabidiolic acid synthase (CBDAS) polypeptide comprising an amino acid sequence of SEQ ID NO:3 with one or more amino acid substitutions, nucleic acids comprising nucleotide sequences encoding said engineered variants, methods of making modified host cells comprising said nucleic acids, modified host cells expressing said engineered variants, methods of producing cannabinoids or cannabinoid derivatives, and methods of screening engineered variants of the cannabidiolic acid synthase (CBDAS) polypeptide.

Optimized cannabinoid synthase polypeptides

The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.

Microorganisms and methods for producing cannabinoids and cannabinoid derivatives

Methods for producing cannabinoids and cannabinoid derivatives

Recombinant microorganisms and methods for producing cannabinoids and cannabinoid derivatives

Growing community of inventors

Berkeley, CA, United States of America

Jeff Wong