Inspyr Therapeutics, Inc.

Genspera, Inc.

Cedarburg Pharmaceuticals, Inc.

Jeff Hutchison

Kevin Kunnen

Xiong Fu

John K Lynch

John E Cabaj

Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.

Methods of producing cancer targeting compounds

Methods of producing cancer treating compounds

Provided herein are methods of making the compound of Formula I: 

Methods of producing cancer compounds

Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.

Preparation of amides of retinoic acid via mixed anhydride and mixed carbonate intermediates

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Sheboygan, WI, United States of America

Jeff Hutchison