Mesoscale Technologies, LLC.

The University of Texas System

Other

Georgetown University

George Sigal

Alan B. Fischer

Charles Clinton

Jeff D. Debad

Alan Kishbaugh

Jacob N. Wohlstadter

James L. Wilbur

Bandele Jeffrey-Coker

Eli Glezer

Kent Johnson

Jeff D Debad

Eli N Glezer

Bandele J Jeffrey-Coker

George B Sigal

Jacob N Wohlstadter

James L Wilbur

Jonathan K Leland

Mark A Billadeau

Alan B Fischer

Charles M Clinton

Joseph M Leginus

Koustubh A Phalnikar

Sriram Jambunathan

Sudeep Kumar

Michael Warnock

Gisbert Spieles

Michael Tsionksy

Sudeep M Kumar

Michael Tsionsky

Charles A Wijayawardhana

John H Kenten

Niranjan Y Sardesai

Hans Biebuyck

Robert M Umek

Paula Denney Eason

Cindy V Ly

Allen J Bard

Mark Burns

Arianna Biesso

Joshua Gatson

Cindy Ly

Jeffrey-Coker Bandele

Jambunathan Sriram

Eli N Glazer

Eli Glazer

The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1β, IL-2, IL-6, IL-10, IL-22, IP-10, TNFα, TSLP, NFL, and/or NFH.

Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury

Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Methods for diagnosing an inflammatory bowel disease based on soluble tumor necrosis factor II (sTNFRII) levels in a patient sample and treating thereafter

Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

Assay cartridges and methods of using the same

Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Assay plates, reader systems and methods for luminescence test measurements

Methods for evaluation of the effectiveness of a drug or drug candidate in treating an inflammatory bowel disease by use of multiplexed assay kit comprising various biomarkers

Multiplexed assay kit to evaluate the efficacy of treatment for inflammatory bowel disease

Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Methods and apparatus for conducting multiple measurements on a sample

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Gaithersburg, MD, United States of America

Jeff D Debad