Trustees of the Colorado School of Mines

Jeff A Squier

David W M Marr

Tor Vestad

Robert Applegate

Erica K Block

Justin Chichester

A multipass chirped pulse amplification system outfitted with a single-grating, simultaneous spatial and temporal focusing (SSTF) compressor platform is provided. Such a system provides the ability to vary the beam aspect ratio of an SSTF beam, and thus the degree of pulse-front tilt at a focus, while maintaining a net zero-dispersion system. The optical system may include a first optical element or set of optical elements that receives and then varies a pulse-front tilt of a light beam, and a second optical element or set of optical elements that focuses the light beam having the varied pulse-front tilt that is output by the first optical element or set of optical elements. The first optical element or set of optical elements includes an optical grating, two dihedrals, and a retroflector roof mirror.

Integrated single grating compressor for variable pulse-front tilt in simultaneously spatially and temporally focused systems

The direct integration of light and optical control into microfluidic systems presents a significant hurdle to the development of portable optical trapping-based devices. A simple, inexpensive fiber-based approach is provided that allows for easy implementation of diode-bars for optical particle separations within flowing microfluidic systems. Models have also been developed that demonstrate the advantages of manipulating particles within flow using linear geometries as opposed to individually focused point traps as traditionally employed in optical-trapping micromanipulation.

Fiber-focused diode-bar optical trapping for microfluidic manipulation

A system, method, and device for re-orienting and/or deforming cells and other objects is provided. The system, method, and device may include a high-throughput setup that facilitates the ability to orient, deform, analyze, measure, and/or tag objects at a substantially higher rate than was previously possible. A relatively large number of cells and other objects can be deformed, by optical forces for example, as the cells and other objects a flowed through the system.

Growing community of inventors

Golden, CO, United States of America

Jeff A Squier