Leo-pharma A/s

Jef Fensholdt

Bjarne Nørremark

Sophie Elisabeth Havez

Jacob Thorhauge

Bjarne Norremark

The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

Cyclic hydrocarbon compounds for the treatment of diseases

The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R, A, R, X, B, Rare as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use&#x2014;alone or in combination with one or more other pharmaceutically active compounds&#x2014;in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.

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Stenløse, Denmark

Jef Fensholdt