Samsung Electronics Co., Ltd.

Korea University Research and Business Foundation

Cellemedy Co., Ltd.

Korea Institute of Science and Technology

Celemics, Inc.

Jeewon Lee

Heekyung Jeon

Hyemi Lee

Hyunyeul Lee

Jinseon Chang

Wonjun Lee

Eunhae Park

Josef Clinch

Jinhee Kwon

Dongkyun Kang

Jonathan Leonard

Hyun Yeul Lee

Youngseong Kim

Hyosang Bang

Insheik Martin Jung

Yongchae Jung

Bo Ram Lee

Anukam Edward Opara

Koo-Chul Kwon

Hyun Jin Kim

Eun Jung Lee

Jong Hwan Lee

Jinkyo Chung

Bowon Kim

Sukjae Lee

Kwangmeyung Kim

Yong Hyun Kwon

Ju Hee Ryu

Duhee Bang

Sangun Park

Joongoo Lee

Jeong-Hyeok Kwon

Seunghyun Seo

Ho Kyung Ko

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The present invention relates to novel enzyme nanoparticles capable of converting methane into methanol, in which key active sites of methane-oxidizing bacteria are fused with each other and expressed on a protein that can be self-assembled in cells to form nanoparticles, and specifically to enzyme nanoparticles including a protein having methane monooxygenase (MMO) activity and active sites of the methane oxidase, a method for production thereof, a recombinant microorganism into which a nucleic acid encoding the protein and the active site of the methane oxidase is introduced, and immobilized enzyme nanoparticles including the enzyme nanoparticles loaded on a carrier.

Enzyme nanoparticles with methane oxidation activity

The present invention relates to recombinant self-assembling protein nanoparticles presenting an albumin-binding peptide at the surface. For the recombinant self-assembling protein nanoparticles according to the present invention, an albumin-binding peptide can reduce the immunogenicity of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide is presented at the surface, and thus binds to an albumin protein present in vivo, and the albumin-binding peptide can also provide the cancer delivery function of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide binds to albumin around cancer. Simultaneously, the binding of the albumin-binding peptide to albumin can significantly increase the in vivo residence time of the recombinant self-assembling protein nanoparticles, thus increasing the potential for use in various medical applications.

Non-immunogenic protein nanoparticles with cancer targeting activity using albumin-binding peptide

A method for detecting a disease marker using self-amplification of a detection signal is disclosed. The method can include (a) a step of simultaneously inducing an antigen-antibody immune response and an Au particle formation reaction by reduction of Au ions in an assay solution prepared by, to a pre-assay solution in which all of an antibody or antigen for detection of a disease-specific marker, free Au ions, and adsorbed Au ions are present, adding a sample, which contains a disease-specific antigen or antibody binding specifically to the antibody or the antigen, and a reducing agent; and (b) a step of confirming the presence or absence of a disease-specific marker by a chromogenic reaction through the Au particle formation.

Accurate, rapid and convenient single-step disease diagnostic method using self-amplification principle of detection signal

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Growing community of inventors

Seoul, South Korea

Jeewon Lee