American Home Products Corporation

Wyeth

Valneva Austria Gmbh

Emergent Product Development Gaithersburg Inc.

Jee Loon Look

Khawla Abdullah Abu-Izza

Vincent Hon-Kin Li

Krishna P Raman

Joyce H Wilson

Paul Joseph Cooper

Ying Chen

Robert Chancey Seid

Robert Schlegl

Michael Weber

Lakshmi Khandke

Karen Lingnau

Benjamin Wizel

Christoph Klade

Jürgen Wruss

Christoph Reinisch

Robert Seid

Christian Ruiz

Ljubomir Paucz

Ursula Schlosser

Ronald Malone

Hanyoung Han

Zhaowei Jin

Robert C Seid, Jr

Karin Riedl

Cindy Xudong Yang

Xudong Yang

Vincent H Li

Richard William Welch

Nandini Konar

Matthew K Schineller

Graham D Parr

Vladimir G Frolov

Aaron Paul Miles

Christian Fernando Ruiz

Khawla Abdulla Abu-Izza

Vaccine antigen formulations that are stable after undergoing freeze and thaw conditions and methods of preparing the formulations are provided. Methods of using the formulations to prepare vaccine are also provided. Vaccines comprising the formulations are useful, for example, to protect against, inhibit or alleviate a disease or infection, such as related to anthrax infection.

Temperature stable vaccine formulations

The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKLKLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 &#x3bc;m.

IC31 nanoparticles

1C31 nanoparticles

The invention relates to methods for producing storage stable virus compositions. In certain embodiments, the invention relates to one or more formulations and process steps which result in storage stable virus compositions, wherein the composition is storage stable as a lyophilized solid composition or a frozen liquid composition.

Method for producing storage stable viruses and immunogenic compositions thereof

The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.

Formulations which stabilize and inhibit precipitation of immunogenic compositions

A multi-composition stick product, such as a lip balm, sun screen, deodorant, or glue stick. The multi-composition stick product including a stick composition molded in the container so as to contact the walls thereof and be advanceable or ejected therefrom. The stick composition includes a first composition and a second composition. The first and second compositions differ in at least one component, such as a medicament, colorant, fragrance, flavorant, sunscreen, preservative, conditioner, moisturizer, emollient, or surfactant. Furthermore the first and second compositions are arranged in a predetermined non-random pattern that is reproducible. Also described is the method and apparatus for manufacturing the multi-composition stick product.

Multi composition stick product and a process and system for manufacturing same

Multi composition stick product and a process and system for manufacturing the same

The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37&deg; C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.

Fast dissolving tablet

Multi-composition stick product and a process and system for manufacturing the same

Combined multi-composition stick product, such as lip balm, sun screen, deodorant, or glue stick and container therefor

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Mechanicsville, VA, United States of America

Jee Loon Look