Delalande S.a.

Jeannine A Eberle

Claude P Fauran

Guy M Raynaud

Guy R Bourgery

Claude J Gouret

Nicole A Dorme

Bernard M Pourrias

Michel J Turin

Guy R Raynaud

Compounds of the formula ##STR1## IN WHICH R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy. The compounds are prepared by reacting 2-Ar-4-chloropyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.

Pyrimidin-6-yl acethydroxamic acids

Compounds of the formula ##STR1## in which Ar is .alpha.-furyl or .alpha.-thienyl and pharmacologically acceptable salts thereof are provided as novel therapeutic agents which have inter alia utility in treating asthma, respiratory deficiency, visceral spasms, gastroduodenal ulcers or hyperchlorhydria.

1-[2'-(.alpha.-Furoyl or .alpha.-thienoyl)eth-1'-yl]-2-(4'-cinnamyl

Compounds of the formula ##STR1## in which R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy. The compounds are prepared by 2-Ar-4-chloro-pyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.

Pyrimidin-6-yl acethydroxamic acids, their therapeutic application and

A compound of the formula ##SPC1## In which R is hydrogen, hydroxy, halogen or alkoxy containing up to 3 carbon atoms, and ##EQU1## is dialkylamino in which the alkyls contain up to 3 carbon atoms, or pyrrolidino, piperidino, morpholino or hexamethyleneimino, and n is 2 or 3. The compounds are prepared by reacting R substituted benzaldehyde with a 2,3-dihydrobenzofuran derivative and then reducing that reaction product. The compounds possess antihypertensive, hypotensive, vasodilatatory, spasmolytic, diuretic, sedative, anti-arythmic and anti-inflammatory properties.

Certain 6-(dialkylamino, pyrrolidino and

Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.

2-Aminomethyl benzimidazole derivatives

Compounds having the formula ##SPC1## Wherein Y is an aliphatic radical having up to 4 carbon atoms, phenyl, or phenyl substituted by one or more halogens, aliphatic radical having up to 4 carbon atoms, methoxy or trifluoromethyl. The compounds are prepared by reacting epichlorohydrin with benzimidazole substituted at the 2 position by ##EQU1## The compounds possess diuretic, sedative, antiulcerous, analgesic, antiinflammatory and cardiac analeptic properties.

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Chatou, France

Jeannine A Eberle