Angiodynamics, Inc.

Interface Biologics, Inc.

Evonik Canada Inc.

Interface Biologic Inc.

Jeannette Ho

J Paul Santerre

Raymond Lareau

Benjamin Bell

Sanjoy Mullick

Weilun Chang

Alexandra Piotrowicz

Roseita Esfand

Richard Witmeyer

William M Appling

Theodore J Beyer

Carol L Lancette

Mark A Steedman

Jamie Robert Swenor

Antonio Cillero Rodrigo

Kyle William Macdonald

The present invention relates to polyvinvyl chloride (PVC) admixtures with plasticizers and surface modifying macromolecules. In accordance with embodiments, articles formed from the compositions disclosed herein may reduce leaching of plasticizers.

Plasticized PVC admixtures with surface modifying macromolecules and articles made therefrom

The invention relates to ester-linked surface-modifying macromolecules and admixtures thereof as shown below by the representative compounds. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules). 

Ester-linked surface modifying macromolecules

A vascular access catheter is disclosed that has a catheter shaft with a distal end portion with a distal tip having a sloped face that is positioned at an acute angle from the distal tip relative to a longitudinal axis of the catheter shaft. A first, second, and third lumen extend longitudinally through the catheter shaft. The third lumen is configured for receiving a guidewire and may extend a partial length of the catheter or substantially the entire length of the catheter. The first lumen has an aperture located in the angled edge distal end portion of the catheter next to the distal tip and communicates with the first lumen. The second lumen has an aperture that is positioned in the outer surface of the catheter shaft that is in communication with the second lumen, and is spaced proximally from the first lumen aperture. The catheter includes a fluoropolymer additive with specific compositions and/or purity levels.

Dialysis catheters with fluoropolymer additives

A venous access catheter shaft and method of using and manufacturing such a catheter is provided. In one aspect of the invention, a catheter is provided comprising a base polymer having a Shore A durometer of 85A or lower, with 2.0% percent by weight of surface modifier, and a radiopaque filler comprising between 20-40 percentage by weight. In another aspect of the invention, a method reducing thrombus accumulation on a venous access catheter is provided wherein the catheter surface's resistance to thrombus formation is enhanced during indwell time by lowering the durometer rating of the base polymer of the catheter without increasing the amount of surface modifier additive. In another aspect of the invention, a method of manufacturing a catheter shaft is provided, wherein the shaft is formed comprising a base polymer having a Shore A durometer of 85A or lower, with 2.0% percent by weight of surface modifier, and a radiopaque filler comprising 30% by weight barium sulfate, and optionally a colorant of 0.2% weight.

Catheter shaft with enhanced platelet anti-adhesion surfaces

The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.

Thermally stable biuret and isocyanurate based surface modifying macromolecules and uses thereof

The invention relates to admixtures of thermoplastic polyurethane base polymers that resist surface dulling and fluorinated additives and their use in the manufacture of articles, such as medical devices. For example, the admixtures of the invention are useful in the manufacture of blood dwelling medical devices, such as catheters.

Thermoplastic polyurethane admixtures

The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels.

Catheters with high-purity fluoropolymer additives

Catheters with fluoropolymer additives

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Toronto, Canada

Jeannette Ho