General Electric Company

Jeannette Christine Roberts

Matthew David Butts

Andrew Soliz Torres

Binil Itty Ipe Kandapallil

Jason William Castle

Michael James Rishel

Brian James Grimmond

Rong Zhang

The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

Microbubble tether for diagnostic and therapeutic applications

A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R, R, R, R, R, R', R&#x2032;, R&#x2032;, R&#x2032; and R&#x2032; are selected form hydrogen, a protected C-Chydroxyalkyl group, or a C-Calkyl group; R, R&#x2032;are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C-Chydroxyalkyl group, a C-Calkyl group; n is an integer between 0 and 4; R, R&#x2032;are selected from a hydrogen, a protecting group comprising C-Caliphatic radicals, C-Ccycloaliphatic radicals, C-Caromatic radicals, m is an integer between 1 and 10; at least one of Rand R&#x2032;is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.

Contrast enhancement agents and method of use thereof

A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof wherein Ris independently at each occurrence a hydroxy group, a C-Chydroxyalkyl group, or a C-Calkyl group, and b is 0-4; R-Rare independently at each occurrence hydrogen, a C-Chydroxyalkyl group, or a C-Calkyl group, with the proviso that at least one of R-Ris a hydroxy group or a C-Chydroxyalkyl group; and wherein Q is one or more charge balancing counterions; and one or more pharmaceutically acceptable carriers and excipients. The subject is subjected to a diagnostic imaging technique such as magnetic resonance imaging. The technique may be used in a variety of diagnostic imaging regimes, such as imaging of circulatory systems, genitourinary systems, hepatobiliary systems, central nervous systems, tumors, and abscesses among others.

Hydroxylated contrast enhancement agents and imaging method

Growing community of inventors

Brunt Hills, NY, United States of America

Jeannette Christine Roberts