Wilmington Partners L.p.

Vista Scientific LLC

Polymer Technology Corporation

Bausch-lomb Incorporated

Hampton Technologies

Jeanne Y Ellis

Edward J Ellis

Charles D Leahy

Denis LaBombard

A method for forming an ocular drug delivery device includes the steps of: (1) forming a drug core containing an active agent, wherein the drug core has a barrier disposed all surfaces thereof except for a drug release surface which is left free of the barrier; (2) forming a drug release membrane over the drug release surface; and (3) forming the remaining portion of the device body by an overcast (overmold) process.

Method for forming an ocular drug delivery device

The present invention is based on the unexpected finding that the combination of a carboxylate containing anionic polymer, of molecular weight greater than about 1000 daltons, with cleaning agents, provides improved contact lens cleaning preparations. The present invention includes contacting a soiled contact lens with an aqueous solution comprising an anionically charged polymer and a surfactant or surfactant combination selected from the classes of nonionic surfactants, anionic surfactants, and amphoteric surfactants.

Contact lens cleaning solution

Aqueous ophthalmic preparations are provided and are intended to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctival sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a mucin component, similar to that found at the normal human ocular surface and in one exemplary and preferred embodiment, the mucin is a transmembrane or surface mucin.

Mucin containing ophthalmic preparation

The present invention discloses the ophthalmic applications of mucin derived from mammalian milk or milk byproducts. This mucin has been found to be a MUC1 type mucin similar to the transmembrane mucin expressed on the surface of the human eye. The mucin-containing preparations described in this invention can be in the form of an aqueous formulation to be instilled into the eye, or in which to pre-soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctival sac. The preparations disclosed are utilized for the treatment of tear film and ocular surface disorders associated with the signs and symptoms of dry eye. Furthermore, mucin-based formulations are also effective for the relief of symptoms of eye irritation, such as those caused by environmental conditions or by contact lens wear.

Mucin containing ophthalmic preparations

There are disclosed compositions and methods for treating the surface of the eye, or contact tenses to be placed on the eye, with an aqueous composition comprising a quaternary nitrogen-containing ethoxylated glycoside and a therapeutic agent. The subject invention is particularly suited for use with silicone-containing contact lenses. Examples of specific compositions include aqueous solutions of lauryl methyl gluceth-10 hydroxypropyl-dimonium chloride in combination with anionic polysaccharides such as hyaluronic acid.

Ophthalmic composition including a cationic glycoside and an anionic therapeutic agent

Ophthalmic solutions include a material composed of (a) a hydrophobic core having at least three carbon atoms and (b) at least three hydrophilic polyethylene oxide chains attached to the core. Examples of such materials include ethoxylated derivatives of glucose, glycerin, sorbitol, and divinyl benzene.

Composition for wetting contact lenses

A method for treating contact lenses with solutions including a material having (a) a hydrophobic core having at least three carbon atoms and (b) at least three hydrophilic polyethylene oxide chains attached to the core.

Method for wetting contact lenses

A method for treating contact lenses involves irradiation of the contact lens with high energy radiation while immersed in an aqueous medium such as saline solution.

Method of treating contact lenses

Compositions for treating contact lenses, particularly rigid, gas permeable contact lenses, comprise a quaternary nitrogen-containing ethoxylated alkyl glucoside.

Contact lens solution containing cationic glycoside

Methods of treating contact lenses employ a material composed of (a) a hydrophobic core having at least three carbon atoms and (b) at least three hydrophilic polyethylene oxide chains attached to the core.

Improved contact lens compositions are achieved through incorporation of a fluorine containing mono or diester of itaconic acid in siloxane polymeric contact lens compositions. Copolymers include components which modify contact lens mechanical, optical and transport properties as well as surface characteristics to achieve at least some compositions having an oxygen permeability of at least DK35 with a refractive index of from 1.35 to 1.5 and a percent hydration below 2 percent of total weight. Contact lenses made of materials of this invention are highly permeable to oxygen and resistant to the deposition of tear components providing extended wear capability through improved biocompatibility.

Fluorine containing polymeric compositions useful in contact lenses

Multifunctional organopolysiloxane resin systems are provided whose starting materials comprise a reactive vinyl containing silane, a disubstituted silane and a trisubstituted silane hydrolyzed together to form a resin system. The preferred material of the resin system has a viscosity of from 7 to 70 centistokes at 25.degree. C. The preferred material is in the form of a contact lens and also contains an ester and a hydrophilic agent.

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Lynnfield, MA, United States of America

Jeanne Y Ellis