Bioprojet

Societe Civile Bioprojet

Institut National De La Sante Et De La Recherche Medicale

Other

Bioproject

Societe Civile Bioproject

Sun Pharma Advanced Research Company Limited

Centre National De La Recherche Scientifique

Université De Caen

Bioprojet Pharma

Societe Civile Brioprojet

Universite De Caen - Esplanade De La Faix

Camille Georges Wermuth

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Denis Danvy

Xavier Ligneau

Marc Capet

Pierre Duhamel

Lucette Duhamel

Philippe Robert

Claude Gros

Jean-Christophe Plaquevent

Thierry Monteil

Nicolas Levoin

Jean-Michel Arrang

Isabelle Berrebi-Bertrand

Walter Schunack

Monique Garbarg

Holger Stark

Olivier Labeeuw

Thierry Calmels

Xavier Billot

Stéphane Krief

Bruno Giros

Nadine Noel

Charon R Ganellin

Bernard P Roques

Ralph Lipp

Katja Purand

Camille-Georges Wermuth

André Mann

Pierre Sokoloff

Fabrice Garrido

Abdellatif Fkyerat

Olivier Chamard

Serge Piettre

Wasyl Tertiuk

Rajamannar Thennati

Antonio Guglietta

Manuel M Raga

Olivia Poupardin-Olivier

Juan Sallares

Jayraj Dilipbhai Aradhye

Bhavesh Mohanbhai Panchal

Sigurd Elz

Ranjan Kumar Pal

Biswajit Samanta

Helene Greciet

Fabien Leurquin

Marc Maury

David Perrin

Didier Rognan

Jean Charles Schwartz

Marta Guerrero

Jean-Charles M Lancelot

Charon Ganellin

Isabelle Bertrand

Christophe Lusson

Max-Fernand Robba

Muthukumaran Natarajan Pillai

Sandeep Pankajbhai Pathak

Japan Nitinkumar Desai

Marie-Pascale Martres

Sadek Bassem

Michael C O Krause

Nadine Noel-Lefebvre

Monigue Garborg

Jean-Stëphane Julien

Laurent François Gérard Landais

Dijixa Chandubhai Rana

Kaushik Dhanjubhai Prajapati

Marcel Morvan

G&eacute;rard Coquerel

Marie-No&euml;lle Petit

Agnes Quemener

Walter G Schunack

Annette Huls

Jignesh Kantilal Jivani

Reidemeister Sybille

Athmani Salah

Nadia Pelloux-Leon

Charon Robbin Ganellin

Wasyl Tertiux

Laurent Francois Landais

Jean-Stephane Julien

Charon Robin Ganellin

Bhavesh M Panchal

Jayraj D Aradhye

Andre Mann

Stephane Krief

Jean-Stéphane Julien

The present application concerns novel benzimidazole enantiomeric derivatives, their process of preparation and their therapeutical uses as dual H1 and H4 receptor ligands.

Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands

Novel benzimidazole enantiomeric derivatives, their process of preparation and their therapeutical uses as dual H1 and H4 receptor ligands are disclosed.

The present invention concerns new therapeutical uses, including low dosage administration of the highly potent H3-ligand: (3S)-4-{4-[3-(3-methylpiperidin-1-yl)propoxy]phenyl}pyridine 1-oxide.

Therapeutical use of H3-ligands

The present invention concerns the tetrahydrate form of the compound: (3S)-4-{4-[3-(3-methylpiperidin-1-yl)propoxy]phenyl}pyridine 1-oxide, dihydrochloride, its process of preparation and therapeutical uses thereof.

Tetrahydrate of H3 ligand, its process of preparation and pharmaceutical compositions comprising the same

The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. A method is also provided for treating a subject in need thereof by administering the combination of adrenaline with an antidepressant. The pharmaceutical composition is to be administered by injection.

Combination of adrenalin with an antidepressant for use in the treatment of shocks

The present invention relates to a new formulation of an enkephalinase inhibitor, such as racecadotril or dexecadotril, the process for the preparation thereof, and the use thereof in the treatment of diarrhea.

Form of administration of enkephalinase inhibitor

The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation. 

Piperidinyl monocarboxylic acids as S1P1 receptor agonists

The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.

6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepines derivatives as histamine H4 receptor ligands

The present invention concerns novel (aza)benzhydryl ether derivatives which exhibit H4-receptor binding activity. The present invention also concerns their process of preparation and their therapeutical uses.

(Aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications

Benzazole derivatives as histamine H4 receptor ligands

The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.

Dicarboxylic acid derivatives as S1P1 receptor agonists

The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use. 

The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent. 

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The present invention provides new method of treatment of Parkinson's disease, obstructive sleep apnea, narcolepsy, dementia with Lewy bodies, vascular dementia with non-imidazole alkylamine derivatives that constitute antagonists of the H-receptors of histamine.

A method is provided for the treatment of sleep apnea and other conditions wherein an effective amount of crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I): optionally comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2&#x3b8;) at 11.2&#xb0;, 19.9&#xb0;, 20.7&#xb0; and 34.1&#xb0;&#xb1;0.2&#xb0; is administered to a patient in need thereof.

Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy]propyl]-piperidine

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Paris, France

Jeanne-Marie Lecomte