Schering Corporation

Intervet Inc.

Merck Sharp + Dohme Corp.

Schering-plough Animal Health Corporation

Intervet International B.v.

Jeanine D Mattson

Daniel M Gorman

Terrill K McClanahan

Rene De Waal Malefyt

Mohamad A Morsey

Christi L Parham

Theodore R Sana

Erin E Murphy

Jeffery Grein

Hirokazu Kurata

Naoko Arai

Chetan Savkoor

Kathleen M Smith

Maribel Beaumont

Jennifer R Louten

Daniel E Gorman

The present invention relates to biomarker responsive to treatment with an anti-Thymic Stromal Lymphopoietin (TSLP) antibody.

Biomarkers for TSLP treatment

The present invention discloses a canine TSLP protein and a nucleic acid that encodes that protein. Peptide fragments of the protein that comprise specific epitopes of the canine TSLP protein are also disclosed. The canine TSLP protein and related peptide fragments may be used as an antigen for immunological assays, as well as for vaccines that induce anti-TSLP antibodies. The present invention further discloses methods of making and using the canine TSLP gene, the canine TSLP protein, and the related peptide fragments.

Canine thymic stromal lymphopoietin protein and uses thereof to treat allergic symptoms

Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

Nucleic acids encoding TNF&#x3b3;

Nucleic acid encoding TNFx protein

Fusion proteins comprising canine thymic stromal lymphopoietin protein and uses thereof

The present invention provides isolated nucleic acid molecules that encode a substantial part of canine RANKL polypeptide, including the extracellular domains of that polypeptide, the polypeptide and fragments thereof. Vectors and host cells encoding and expressing canine RANKL polypeptide are provided, as well as antibodies that bind to RANKL and that inhibit RANKL activity. Also provided are methods of treating an animal to inhibit or treat the loss of bone minerals.

Canine RANKL and methods for preparing and using the same

Canine thymic stromal lymphopoietin protein and uses thereof

Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.

Mammalian cell surface antigens; related reagents

Antibodies to mammalian T cell surface antigen

Mammalian cell surface antigens: related reagents

Growing community of inventors

San Francisco, CA, United States of America

Jeanine D Mattson