Sanofi

Roussel Uclaf

Jeanine Cleophax

Jean-Claude Barriere

Stephan Gero

Andre Cier

Stephane Gero

Alice Gateau-Olesker

Novel 2-azetidinones of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, --OH, protected hydroxy and --OCH.sub.2 --COOR', R' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sub.2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms and hydroxyl protective group and a novel process and novel intermediates for their preparation and a process for the preparation of compounds of the formula ##STR2## wherein R has the above definition, R'd is selected from the group consisting of hydrogen, --OH and protected hydroxyl and R.sub.3 is selected from the group consisting of hydrogen and R.sub.3 ', R.sub.3 ' is amino protective group which are useful intermediates.

Optically active 4-carbalkoxy-2-azetidinones

Prostanoic acid derivatives represented by the general formula: ##STR1## in which X represents hydrogen or hydroxy, X.sub.1 represents hydrogen or X and X.sub.1, when they are taken together with the carbon atom to which they are attached, represent a carbonyl group and Z represents hydrogen or hydroxy and pharmaceutically acceptable alkali metal salts thereof. They can be used as bronchodilators and/or inhibitors of blood-platelet aggregation.

Hetero-prostaglandin derivatives and processes for preparing them

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Palaiseau, France

Jeanine Cleophax