Mixture Sciences, Inc.

Mimetogen Pharmaceuticals, Inc

Lama, Teresa

Pascal, Jeanick

Jeanick Pascal

Richard Allen Houghten

Michael J Moran

Teresa Lama

The present invention relates to methods of preparing &#x3b2;-turn cyclic peptidomimetic compounds and intermediates thereof. Particularly, the present invention relates to a process for the synthesis of &#x3b2;-turn cyclic peptidomimetic compounds of formula I: where R, R, R, R, R, R, R, L, X, Y and n are as defined in the specification. The present invention provides a more efficient route for preparing &#x3b2;-turn cyclic peptidomimetic compounds and intermediates thereof.

Synthesis of beta-turn peptidomimetic cyclic compounds

A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.

Volatilizable solid phase supports for compound synthesis

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San Diego, CA, United States of America

Jeanick Pascal