Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Jean-Yves Puy

Jean-Louis Imbach

Pascal Clayette

Philippe Fretier

Joel Oiry

Joël Oiry

The invention concerns compounds of general formula (I) (wherein R and R' represent an alkyl radical or an aryl group and R&#x2033; is hydrogen or a CO&#x2014;Rgroup wherein Ris an alkyl radical or an aryl group; and the dimers formed by the disulphide bond from one and/or the other of the two sulphur atoms of the compounds of general formula (I); and the corresponding thiazolidin forms), the methods for preparing them and uses thereof. More particularly, it concerns the use of said compounds as antioxidant agents, in particular for preparing medicines designed to increase the intracellular and/or extracellular level of glutathione (GSH).

Antioxidants, preparation methods and uses

The invention concerns a process for preparing compounds of general formula (I)wherein R and R' represent an alkyl radical or an aryl group; and R&#x2033; is hydrogen or a CO&#x2014;Rgroup wherein Ris an alkyl radical or an aryl group; and wherein these compounds are or not in the thiazolidine form; by protecting the N-acyl-L-cysteine to form an intermediate compound; and then by coupling said intermediate compound with S-acylcysteamine hydrochloride or with thiazolidine.

Antioxidants, preparation processes and their uses

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Montpellier, France

Jean-Yves Puy