Institut National De La Sante Et De La Recherche Medicale

Biogen Ma Inc.

Biogen Idec Ma Inc.

Université Paris 7—Denis Diderot

Institut Des Vaisseaux Et Du Sang

Jean-Sebastien Silvestre

Anthony Rossomando

Radia Tamarat

Philippe Foubert

Sophie Le Ricousse-Roussanne

Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.

Compositions and methods for increasing vascularization

A cell/ligand specific marking system, the system being characterized in that it comprises: (a) an endothelial precursor cell (EPC) including a cell marker selected from among the group consisting of the Eph (in particular EphB4 or EphB1), and (b) a protein material of structure L-K, which consists of a ligand (L) specific of the marker and is associated or fused with a binding protein (K), the system being capable of providing a proangiogenetic cell material of structure EPC-Eph-L-K. The invention also concerns the cell material as product capable of stimulating angiogenesis, its preparation method and its therapeutic use, in particular with respect to vascular insufficiencies.

Cell/ligand marking system, wherein the marker is of Eph type, cell material comprising said system, method for preparing same and proangiogenetic use

Methods for increasing vascularization

Growing community of inventors

Paris, France

Jean-Sebastien Silvestre