Centre National De La Recherche Scientifique

Université Paul Sabatier (toulouse Iii)

Institut Claudius Regaud

Institut National De La Sante Et De La Recherche Medicale

Jean-Sébastien Hoffmann

Christophe Cazaux

Jean-Christophe Bourdon

Henri Roche

Alice Machado Da Silva

Anne Vidal-Fernandez

The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of the patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, the signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the the expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness from the comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.

Signature for the diagnosis of lung cancer aggressiveness and genetic instability

The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.

Signature for the diagnosis of cancer aggressiveness and genetic instability

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Toulouse, France

Jean-Sébastien Hoffmann