Neurotell Ag

Lafon Pharma S.a.

Societe De Recherche Auvergnate Pour L'innovation En Oligotherapie-Inolig

Jean Rapin

Jacques Gonella

Jean-Marie Grumel

Hans Klaus Witzmann

Dat Xuong Nguyen

Thadee Staron

Dat-Xuong Nguyen

Jean Daver

Patrick Lambropoulos

The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy formula (I), wherein X represents OH, (C)alkoxy, NH, NH&#x2014;C-alkyl, N(Calkyl); Ris a residue derived from any of the amino acids Phe, Tyr, Trp, Pro, each of which may optionally be substituted by a (C) alkoxy group, a (C) alkyl group or a halogen atom, and Ala, Val, Leu, or Ile; Ris a residue which is derived from any of the amino acids Gly, Ala, Ile, Val, Ser, Thr, His, Arg, Lys, Pro, Glu, Gln, pGlu, Asp, Leu and Asn; Rand Rindependently represent H, OH, (C1 &#x2013;C5) alkyl, or (C)alkoxy, provided that Rand Rare not both OH or (C)alkoxy; Rrepresents H, OH, (C)alkyl or (C)alkoxy; and wherein Rpreferably represents a cinnamoyl residue; or pharmaceutically acceptable salts thereof.

Tripeptide derivatives for the treatment of postlesional diseases of the nervous system

The invention relates to the use of specific tripeptides for the treatment of neurodegenerative diseases, and to pharmaceutical compositions comprising the tripeptides. The tripeptide derivatives satisfy the following formula (I): wherein X represents OH, (C) alkoxy, NH, NH&#x2014;C-alkyl, N(Calkyl); Ris a residue derived from one of the amino acids Phe, Tyr, Trp, Pro, which each may be optionally substituted with one or more (C)alkoxy groups, (C)alkyl groups or halogen atoms, as well as Ala, Val, Leu or Ile; Ris a residue derived from one of the amino acids Gly, Ala, Ile, Val, Ser, Thr, Leu and Pro; Yand Yindependently from each other represent H or (C)alkyl; Rand Rindependently from each other represent H, OH, (C)alkyl or (C)alkoxy, provided that Rand Rare not both OH or (C)alkoxy; and Rrepresents H, OH, (C)alkyl or (C)alkoxy; or a pharmaceutically acceptable salt thereof.

Tripeptides and tripeptide derivatives for the treatment of neurodegenerative diseases

The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy the following formula (I): (see formula I as in paper form) wherein X represents OH, (C) alkoxy, NH, NH&#x2014;C-alkyl, N(Calkyl); Ris a residue derived from one of the amino acids Phe, Tyr, Trp, Pro, which each may be optionally substituted with one or more (C) alkoxy groups, (C) alkyl groups or halogen atoms, as well as Ala, Val, Leu or Ile; Ris a residue derived from one of the amino acids Gly, Ala, Ile, Val, Ser, Thr, and Pro; Yand Yindependently from each other represent H or (C) alkyl; Rand Rindependently from each other represent H, OH, (C) alkyl or (C) alkoxy, provided that Rand Rare not both OH or (C) alkoxy; and Rrepresents H, OH, (C) alkyl or (C) alkoxy; or a pharmaceutically acceptable salt thereof.

Tripeptides and tripeptide derivatives for the treatment of postlesional disease of the nervous system

Guanylic acid derivatives and their use as drugs

The subject of the invention is the choline diethyl-dithiocarbamate having the following structural formula: ##STR1## as well as a process for its preparation from choline chloride and sodium diethyl-dithio-carbamate trihydrate. This substance is useful in the treatment of degenerative brain diseases.

Dithiocarbamate-choline adduts and use thereof in treatment of brain

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Paris, France

Jean Rapin