Centre National De La Recherche Scientifique

Jean-Pierre Zanetta

Pierre Potier

Claude Thal

Dolor Renko

Monique Sensenbrenner

Marie-Madeleine Portier

Herbert Koenig

Janine Koenig

Catherine Quirosa-Guillou

Sabine Kuchler

Jean-Marie Warter

Guy Vincendon

Guanidine derivatives are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies. The compounds have the formula: ##STR1## wherein R.sub.1 is an isopropyl radical, a benzyl radical which is optionally substituted by one or more (C.sub.1 -C.sub.6)alkoxy radicals or a radical: ##STR2## R.sub.2, R.sub.3 and R.sub.4 together with the nitrogen atoms to which they are attached and the carbon atom to which the said nitrogen atoms are attached form a pyrimidine ring of formula II or a pyrimidinium ring of formula IIa: ##STR3##

Compounds having a guanidine structure and pharmaceutical composition

Compounds having a guanidine structure

The invention relates to the use for the diagnosis of demyelinating neuropathies, in particular multiple sclerosis or MS, of endogenous lectins having an affinity for glycans rich in mannose or their protein subunits, these lectins or their subunits being immunologically related to the cerebellar soluble lectins (CSL or their protein subunits, respectively).

Agents for the diagnosis of demyelinating neuropathies, in particular

Growing community of inventors

Griesheim/Souffel, France

Jean-Pierre Zanetta