Rhone-Poulenc Rorer S.a.

Rhone-Poulenc Sante

Jean-Pierre Pulicani

Jean-Dominique Bourzat

Alain Commercon

Herve Bouchard

Didier Morel

Alain Commercedillaon

Herv E Bouchard

Marie-Celine Caude

This invention relates to a process for preparing taxoid derivatives of formulae II and XI: ##STR1## in which Ar represents an aryl radical; R.sub.1 represents a benzoyl radical or a radical R.sub.2 --O--CO-- in which R.sub.2 represents an unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl, or saturated or unsaturated heterocyclic radical; R.sub.3 represents an unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, saturated or unsaturated heterocyclic, or aryl radial, but not a phenyl radical; R.sub.4 represents a hydrogen atom and R.sub.5 represents a hydroxyl-protecting group or R.sub.4 and R.sub.5 together form a heterocyclic group; G.sub.1 represents a hydroxyl-protecting group; and G.sub.2 represents an acetyl radical or hydroxyl-protecting group; by electrolytically reducing a protected taxoid compound in an electrolyte comprising a quaternary ammonium salt which is soluble in an organic solvent or in an aqueous/organic mixture at a controlled potential.

Taxoids, their preparation and the pharmaceutical compositions which

This invention relates to taxoids of general formula (I), their preparation and the pharmaceutical compositions which contain them. The products of general formula (I) have notable antitumoral properties. In the general formula (I),

Metallic rhodium is recovered from aqueous solutions of spent catalysts by acidification and oxidation followed by electrolysis.

Electrochemical process for recovering metallic rhodium from aqueous

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Antony, France

Jean-Pierre Pulicani