Synthelabo

Sanofi-synthelabo

Jean-Pierre Merly

Pascal George

Benoit Marabout

Philippe Michel Manoury

Mireille Sevrin

Jacques Froissant

Dennis C Bigg

Christian Maloizel

Michel Mangane

David Machnik

Daniel C Obitz

Michel Peynot

Jacques Menin

Daniele De Peretti

Corinne Veronique

Jocelyne Roy

8-azabicyclo&lsqb;3.2.1&rsqb; octane-3-methanamine derivatives as ligands of D2 and D3 dopamine and 5HT1A and 5HT2 serotonin receptors

A compound which is a carboxamide derivative of general formula (I) ##STR1## in which R represents a hydrogen atom, a methyl group or a phenoxyalkyl group of general formula ##STR2## in which X represents one or more substituents independently chosen from hydrogen, fluorine, chlorine, methyl, 1-methylethyl and methoxy and

2-piperidinylpyrimidine-4-carboxamide derivatives, and their use in

A compound which is a 2-aminopyrimidine carboxamide derivative represented by formula (I) ##STR1## in which X represents hydrogen, fluorine, chlorine, methyl, 1-methylethyl or methoxy, with the proviso that more than one substituent X may be present in which case each X may be the same or different,

2-aminopyrimidine-4-carboxamide derivatives, their preparation and their

Compounds corresponding to the general formula (I) ##STR1## in which n=2 or 3, X=H, F, Cl or OCH.sub.3, R=H or CH.sub.3, R.sub.1 =H or CH.sub.3, R.sub.2 =alkyl, hydroxyalkyl, (hydroxy)(methoxy)alkyl, dimethoxyalkyl, 2-(aminosulphonyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(methylsulphonylamino)ethyl, aminocarbonylmethyl which is optionally substituted by nitrogen, phenylethyl which is optionally substituted, pyrimidinylaminoalkyl or arylcaronylaminoalkyl, or else R.sub.1 and R.sub.2 form, with the nitrogen which carries them, a piperidine, morpholine, thiomorpholine or piperazine ring, optionally substituted by nitrogen. Use in therapeutics.

A compound which is a 2-aminopyrimidine-4-carboxamide derivative represented by general formula (I) ##STR1## in which m represents 2 or 3,

2-aminopyrimidine-4-carboxamide derivatives, their preparaton and their

[(1-Arylpyrrolidin-2-yl)methyl]piperazine compounds corresponding to the formula ##STR1## in which Z denotes a group of formula N-R.sub.1 in which R.sub.1 is either a hydrogen atom or a C.sub.1-3 alkyl group or a group of formula Ar--C.sub.n H.sub.2n in which n denotes 0, 1 or 2 and Ar denotes a phenyl group optionally substituted by one or more halogen atoms and/or C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals, or a group of formula COR.sub.2 in which R.sub.2 denotes the CH.sub.3, C.sub.6 H.sub.5, CH.sub.2 C.sub.6 H.sub.5 or OC.sub.2 H.sub.5 group and their salts of addition to pharmaceutically acceptable acids. The compounds are useful for the treatment of neurological disorders.

[(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their preparation

A compound of formula (I) ##STR1## in which n denotes 2, 3, 4, or 5,

2-Aminopyrimidine-4-carboxamide derivatives, their preparation and their

A benzazepine derivative which is a compound of formula (I): ##STR1## in which each of m and n denotes the number 1, or

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Sceaux, France

Jean-Pierre Merly