L'oreal

Novartis Ag

Societe Anonyme Dite: L'oreal

Societe L'oreal Sa

Jean-Pierre Laugier

Philippe M Touzan

Evelyne Segot

Marie-France Rude

Constantin Koulbanis

Jean-Francois Nadaud

Francoise Gagnebien-Cabanne

Liliane Ayache

Sabine Deprez

Francois Ringenbach

Gerard Lang

Jean-Thierry Simonnet

Serge Forestier

Claude Bouillon

Dominique Bernard

Jacqueline Griat

Etienne Soudant

Jean-Claude H Ser

Roland M Bazin

Georges Philippossian

Elisabeth Picard

Sylvie Cupferman

Louis L Marcotte

Gerard Obadia

Isabelle Le Royer

Francois Rigenbach

Fran&ccedil;ois Rigenbach

Jean Paul Boelle

Danielle Ravaux

Francedillaois Rigenbach

The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C -C glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.

Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions

A composition for topical use, comprising an oil-in-water emulsion formed from lipid vesicles consisting of oily globules, each having a lamellar liquid crystal coating obtained from at least one surfactant, dispersed in an aqueous phase containing at least one hydrophilic acidic active agent but which does not contain a gelling agent.

COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONSISTING OF AN EMULSION OF THE OIL-IN-WATER TYPE FORMED FROM LIPID VESICLES DISPERSED IN AN AQUEOUS PHASE CONTAINING AT LEAST ONE HYDROPHILIC ACIDIC ACTIVE AGENT

The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.

Use of hydrophilic penetration agents in dermatological compositions for

Treatment of seborrhoea/cutaneous disorders with octoxyglycerol

Anhydrous, stable retinol-based cosmetic or pharmaceutical composition for the skin. This composition contains solubilized retinol in an organic solution which is liquid at ambient temperature and which is chosen from the group comprising:

Anhydrous stable retinol based cosmetic or pharmaceutical composition

Cosmetic compositions containing water having a mineralization of at least 400 mg/l and an active agent having an irritant side effect exhibit a reduced irritant effect; the water is especially a thermal spring water and/or mineral water and the active agent is especially a keratolytic agent of the salicylic acid derivative type.

Cosmetic and/or dermatological composition containing thermal spring

Application of a compound having at least one sulfonic acid functional group which is at least partially non-neutralized, in a cosmetic or dermatological composition, to the skin is useful for treating intrinsic ageing of the skin.

Use of sulfonic acids as anti-ageing agents in a cosmetic or

The invention relates to a stabilized, cosmetically and/or dermatologically acceptable emulsion intended to moisturize the skin. This emulsion contains a fatty phase, an aqueous phase, at least one emulsifying agent and at least one moisturizing agent. The aqueous phase contains at least one phosphated compound capable of releasing, via an enzymatic reaction when it is in contact with the skin, an active agent other than the moisturizing agent, which promotes moisturization of the skin, and the fatty phase contains at least one silicone-containing gum and/or one perfluoro oil. The emulsion according to the invention makes it possible to combat ageing of the skin, acne, pigmentation of the skin and/or hair loss.

Stabilized emulsion intended to moisturize the skin, and use thereof

Use of a glyceryl tri(.alpha.-hydroxyacylate) in a cosmetic and/or dermatological composition as the sole precursor of glycerol and of hydroxy acid, which is capable of releasing the glycerol and the hydroxy acid onto the skin via an enzymatic reaction, in order to moisturize and soften the skin. Useful especially for moisturizing and/or treating dry skin.

Cosmetic and/or dermatological composition containing a glyceryl tri(.alpha

The solubilization of salicylic acid derivatives, and in particular of 5-n-octanoylsalicylic acid, is achieved by mixing the salicylic acid derivative with a vegetable oil. The obtained compositions are useful, in particular, for treating acne and ageing.

Cosmetic and/or dermatological compositions containing salicylic acid

Pharmaceutical composition for topical application to the skin, comprising an oil-in-water emulsion containing dithranol. This composition contains, in order to prevent the oxidation of the dithranol, nonionic vesicles prepared from a lipid phase containing at least one nonionic amphiphilic lipid. These vesicles are dispersed in the aqueous phase of the emulsion.

Pharmaceutical composition for topical application containing dithranol

An antifungus composition in dry spray form contains in combination at least one antifungus agent of the family of allylamines, a noncyclized silicone polymer, a mineral or organic charge and a gas propellant. This composition is useful in the treatment of mycoses.

Antifungus composition in dry spray form

The process consists in dissolving a corticosteroid in the lipid phase of nonionic amphiphilic lipid vesicles consisting of one or more lipid lamellae. Composition for carrying out the above process, in which the vesicles are dispersed in an aqueous phase D, have an average diameter of between 10 and 5,000 nm and contain as corticosteroids 17- and/or 21-mono- or -diesters of hydrocortisone, cortisone, prednisone, prednisolone or 6-methylprednisolone, the corticosteroids representing 0.5 to 2.5% by weight of the total lipids of the lamellae.

Growing community of inventors

Antony, France

Jean-Pierre Laugier