Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie

Saint-gobain Glass France

Jean-Pierre Jolivet

Daniel Scherman

Serge Maitrejean

Didier Gourier

Sophie Cassaignon

Michel Bessodes

Corinne Chaneac

Quentin Le Masne De Chermont

Fabienne Sylvie Pelle

Magali Koelsch

Didier Louis Gourier

Fabienne Julie Pelle

Valérie Goletto

Hanno Kamp

The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.

Persistent luminescence nanoparticles used in the form of a diagnosis agent for in vivo optical imaging

The invention relates to a novel form of titanium oxide. The titanium oxide is characterized in that it has the crystallographic structure of rutile with an orthorhombic lattice and a Pnmm space group, it has a platelet morphology, the platelets being of rectangular shape with a length between 3 and 10 nm, a width between 3 and 10 nm and a thickness of less than 1 nm and it has a specific surface area, determined by nitrogen adsorption/desorption, of 100 to 200 m/g. Applications: self-cleaning glazing, photovoltaic cells.

Titanium oxide with a rutile structure

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Vaugrigneuse, France

Jean-Pierre Jolivet