Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université´ D'aix-marseille

Universidad De Navarra

Université De La Méditerranée - Aix-marseille II

Jean-Pierre Gorvel

Raquel Conde-Alvarez

Vilma Arce Gorvel

Maite Iriarte

Ignacio Moriyon

Jacques F Banchereau

Eynav Klechevsky

Sangkon Oh

Anna Martirosyan

Cyclic beta glucan compounds function as an immunoadjuvant when administered prior to, concommitantly with, or subsequent to the administration of one or more antigens to a subject. These adjuvant compounds may be effectively used as dendritic cell activating molecules.

Immunoadjuvant compounds and uses thereof

The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.

Modified gram-negative bacteria for use as vaccines

Growing community of inventors

Marseille, France

Jean-Pierre Gorvel