Behringwerke Aktiengesellschaft

Laboratoires Hoechst S/a

P C U K Produits Chimiques Ugine Kuhlmann

Hoechst Aktiengesellschaft

Negma-lerads

Laboratories Hoechst S.a.

Laboratoires Hoechst

Jean-Pierre Gesson

Jean-Claude Jacquesy

Klaus Bosslet

Claude Monneret

Michel Koch

Jean-Claude Florent

Francedillaois Tillequin

Dieter Hoffmann

Martine Mondon

Michel Azoulay

Cenek Kolar

Jorg Czech

Marie-Paule Jouannetaud

J Org Czech

Gerhard Dickneite

Gerhard Seemann

Hans P Kraemer

Hans H Sedlacek

Manfred Gerken

Hans-Ulrich Schorlemmer

Suzy Charbit

Hervé Ficheux

Francois Schutze

Roland Hoos

Dieter Hoffman

Brigitte Renoux

Gilbert Gaudel

Nadia Fonteneau

Jean-Claude Jacquessy

Patricia Petit Nee Monpontet

Abdallah A Abdallah

The invention concerns novel flavone and isoflavone derivatives of formulae (Ia) and (Ib) wherein: X represents a group of formula &#x2014;COOR, or &#x2014;PO(OR); R represents a hydrogen atom or an alkaline or alkaline-earth metal, or a lower alkyl group; Rrepresents a hydroxy group, a lower alkoxy group or an acyloxy group; Rand R, identical or different, represent a hydrogen or halogen atom, or a trifluoromethyl group, a trichloromethyl group, a hydroxy group, an alkoxy group or an acyloxy group comprising 1 to 5 carbon atoms, or Rand Rcan combine to form an alkylene dioxy group. The invention is useful for rheumatic diseases.

7-carboxy-flavone derivatives preparation method and therapeutic use

Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.

Prodrugs, their preparation and use as pharmaceuticals

Prodrugs their preparation and use as pharmaceuticals

Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.

Pro-prodrugs, their production and use

Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.

Prodrugs for enzyme mediated activation

Glycosylated prodrugs, their method of preparation and their uses

The present invention relates to new anthracyclines corresponding to the general formula I below: ##STR1## in which R' and R', which may be identical or different, denote a hydrogen atom (and in this case R' is different from R') or the group --(CH.sub.2).sub.n --R.sub.1 --(CH.sub.2).sub.m --R.sub.2 where n is between 1 and 6,

Anthracyclines and drugs containing them

The present invention relates to new aglycons which correspond to the general formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.5, which can be identical or different, represent a hydrogen atom or a group OH, OMetal or OR.sub.4, R.sub.4 being a substituted or unsubstituted C.sub.1 to C.sub.6 alkyl group,

Aglycons

Process for hydroxylating alkylphenols in which the carbon atoms of the alkyl group bonded to the aromatic nucleus has at least one hydrogen atom bonded thereto and the phenolic ethers thereof, at the meta position relative to the phenol or ether function, by reacting the phenol compound with an aqueous hydrogen peroxide solution in the presence of a liquid superacid at low temperature.

Process for the meta-hydroxylation of alkylphenols and the ethers

Process for the isomerization of ortho- and para-bromophenols or the ethers thereof into corresponding meta-brominated derivatives by isomerizing ortho- and para-bromophenols in the corresponding ethers in the presence of a liquid superacid at a temperature in the region of ambient temperature.

Process for the isomerization of ortho-and para-bromophenols or the

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Chansseneuil du Poitou, France

Jean-Pierre Gesson