Corvita Corporation

Jean-Pierre Georges Dereume

Leonard Pinchuk

David C MacGregor

Modular endoluminal stent-grafts include at least two different sized stent-grafts which are deployed one within the other. According to one embodiment of the invention, a first stent-graft is provided having a flared end which is expandable to a first diameter and a midsection which is expandable to a second diameter smaller than the first diameter. A second stent-graft is also provided having an end which is expandable to a diameter which engages the midsection of the first stent-graft. The first embodiment of the invention is deployed by expanding the first stent-graft such that its flared end engages a large diameter vessel, then expanding the second stent-graft inside the midsection of the first stent graft and inside a small diameter vessel such that the second stent graft engages the small diameter vessel and the midsection of the first stent-graft. According to a second embodiment of the invention, the midsection of the first stent-graft is reinforced with a flexible member to restrict the midsection from ballooning. According to other aspects of the invention, the first stent-graft is provided with two flared ends and the second stent graft is provided with or without flared ends. According to still another embodiment of the invention, three or more stent-grafts of different expanded diameter are deployed one within the other.

Modular endoluminal stent-grafts and methods for their use

An endoluminal graft which is both expandable and supportive is provided either in a longitudinal form or in a bifurcated form. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A cover, liner, or a liner, or both a cover and a liner are applied to the endoprosthesis in the form of a stretchable wall material that is porous, elastomeric and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. Preferably, the elastomeric wall material is a polycarbonate urethane.

Expandable supportive endoluminal grafts

A luminal endovascular graft or endoprosthesis having a tubular support which expands between a first diameter and a second, larger diameter is provided with an expandable porous coating which is applied over either or both of the internal cylindrical surface and the external cylindrical surface of the tubular support. The first diameter allows the introduction of the luminal endoprosthesis into human or animal body passages. The expandable coating preferably is made from biocompatible fibers formed into a structure which allows normal cellular invasion upon implantation, without stenosis or restenosis, when the support element is at its second diameter.

Luminal graft endoprotheses and manufacture thereof

Luminal graft endoprostheses and manufacture thereof

An endoluminal graft which is both expandable and supportive is provided in a form suitable for use in a bifurcated body vessel location. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A cover, a liner, or both a cover and a liner are applied to the endoprosthesis in the form of a stretchable wall material that is porous, elastomeric and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. The supportive endoluminal graft is preferably provided as a plurality of components that are deployed separately at the bifurcated body vessel location.

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Brussels, Belgium

Jean-Pierre Georges Dereume