Dionex Corporation

Kontron Instruments Holding Nv

Lc Packings International

L C Packings, Nederland B.v.

Jean-Pierre Chervet

Remco Swart

Johannes Petrus Cornelus Vissers

Johannes Petrus Vissers

Pierre Salzmann

Remco E Van Soest

A reconfigurable multi-mode post-column analysis system improves resolution of liquid chromatography detection data by providing a parking or MS/MS detection mode in which flow of column eluent is substantially reduced to provide greater analysis time within a single eluting detection peak. A micro switching valve unit is reconfigurable between normal (MS) mode that passes column eluent directly to an MS unit, and a peak parking (or MS/MS) mode, in which normal mode column flow is interrupted, and the gradient halted, while more slowly flowing the detection peak of interest through the MS unit. A micro syringe pump contributes to the substantially lower MS/MS flow rate. A MS control unit controls micro switching valve valves to reconfigure between MS and MS/MS modes. After a detection peak, MS mode is reestablished, and the system primary pump returns to normal mode flow rate and gradient conditions. Mode changes can be carried out for each chromatogram detection peak.

Method and system for peak parking in liquid chromatography-mass spectrometer (LC-MS) analysis

A liquid chromatography micro-autosampler is disclosed that permits the sampling of very small samples quantities at high accuracy, while minimizing extracolumn band broadening. The autosampler employ a sample intake tubing connected to the injection valve, that is further connected to an aspirating device. The intake tubing terminates within the hollow bore of a needle which is used to penetrate sample containers. Improved injection profiles are obtained by minimizing injection plug dispersion with back flushing of the injection plug and a low dispersion injection routine and extremely small sample quantities can be handled with a micro pick-up injection routine.

Fully automated micro-autosampler for micro, capillary and nano high

A method of analyzing fluid samples using a bent capillary flow cell, in which method an external UV/visible light ray beam is directed into an elongated section of the flow cell from a bend thereof, this incident light ray beam is limited to a solid acceptance angle .OMEGA.. This solid acceptance angle .OMEGA. is determined such that light rays which enter the elongated section traverse predominantly the longitudinal axis thereof, i.e. propagate through the fluid sample, providing an improved S/N ratio. Lens means, such as ball lenses, may be used at the entrance and exit side of the elongated section. A bent capillary flow cell is provided, in which the elongated section deviates by an angle .psi. from a line N perpendicular to a flat side face of a holding template.

Method of and a capillary flow cell for analysing fluid samples

A capillary flow cell in which a capillary (9) partially extends along the optical path of the cell and has its two end portions (12,13) bent to achieve an essentially Z-shaped configuration. A template (1) has a central bore (2) in which the middle part (11) of the capillary (9) is positioned. A method of manufacture of this capillary flow cell comprises the steps of

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Amsterdam, Netherlands

Jean-Pierre Chervet